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There are case reports and pharmacovigilance signals about rare but concerning events, including new or worsening depression and, in isolated instances, suicidal ideation

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Semaglutide treatment reduces adipocyte size in animals with metabolic syndrome We performed histological analysis on HE-stained slices of visceral adipose tissue to evaluate the association between weight loss and the reduction in white adipose tissue after treatment with semaglutide

Evidence level: Misleading framing Sources: ClinicalTrials.gov exact-name search, accessed 2026-07-12 How to read this: The absence of human trials means human adverse effects are largely unknown